all programs are typically x64 compatible. For example, the entire adobe master collection (with the exception of photoshop) is 32bit native. But it installs just fine on a 64bit Windows OS. The same goes for ZBrush- it has no native 64bit version, it’s just a 32bit app running on a 64bit system.
All 32bit apps are given a 4gb RAM limit on x64, when the app is native 64bit the sky is the limit. Meaning the 8GB of ram I have would actually benefit me in ZBrush. I can currently get higher polycounts in Mudbox 2009 than Z3 due to the fact that mudbox is native 64bit and uses as much RAM as I allow.
Not that I particularly NEED higher polycounts at the moment, but to say Zbrush takes ‘full advantage’ of your 64bit OS is misleading to say the least.