Zbrush 3.5 isn’t out yet, but the new zsphere 2 videos are out, and the Zsphere2 seems to be beyond awesomeness:
http://www.pixologic.com/zclassroom/homeroom/
While watching those incredible videos i was wondering something about the keybindings, let me explain:
When i sculpt i use the keys 1, 2, 3, 4… to switch between my brushes
1=standard brush, 2=move brush, 3=clay brush …
i was wondering, will there be a possibility to have those keybindings changing while being in zsphere2 mode ?
Example:
In sculpting mode: 1=standard brush 2=move brush 3= clay brush … etc …
In zsphere2 mode: 1=Sketch1 brush brush 2=Armature brush 3=Bulge Brush … etc …
My english is far from perfect, don’t hesitate to tell me if you don’t understand what i am asking 
