Is there a big difference between the Mac ZBrush 3.2 and the PC 3.5r3? I was curious because I am planning on upgrading to a new desktop and wanted to know if there was a significant difference between the two.
Six to one, half a dozen to the other.
On the PC side you have ZSpheres II and ZSketch, Surface Noise, more sculpting brushes, ZAppLink, Light Box.
On the Mac side you have full GoZBrush implementation for C4D 10+, Maya 2008 and 2009, Modo 302 and 401.
The Mac version of 3.5 is currently in beta testing and will be released as soon as possible. At that point, both PC and Mac will be the same.