For those who wonder if they should upgrade their Linux installations, my ZBrush 4.0 install upgraded to 4R2 just fine. Activation worked. Sculpting, ZSpheres etc. work. Tried even dynamesh, no problems.
Of course, Pixologic can’t support this kind of use, but if you need this kind of set-up, it’s definitely possible…
I have Ubuntu 11.04 and Wine 1.3.28. nVidia drivers.
ZB really works under wine and tablet pen too (I tried in both Ubuntu and Fedora). Just one thing is bad - no icons for ZB projects (ZPR) in LightBox, but you still can open them by double click on their “empty” placeholders.