I am new to Zbrush and want to know if I can import a mesh from another program and start sculpting it without setting up UVs first?
Cheers
yes you can!
in fact it saves memory to sculpt and polypaint a mesh that doesn’t have UVs. After you finish your sculpting and painting, you can export the lowest subdivision, unwrap it in another program, then back in Zbrush while still on the lowest subdivision, import the unwrapped model. Zbrush will then project all the sculpting and painting onto the unwrapped model. Or you could use UV master, depending on your needs 
Thanks for the quick reply. I will play around with this…Thanks