Hey,
i solved some issues with my topology…first…after reimport into ZBrush there is no dialog “Transfer High-Resolution Details…”…i think this message does not appera because i make many changes in anoter 3D-App! Maybe too much!
So i made the changes on the topology and import it directly into ZBrush. With the function “Project All” i transfered all the details from the original model to the new one. And here is the little problem…on the fingernails there are some artifacts…it seems that the “Project All” - Function does not work exactly enough…so what is the best way to transfer all Modeling/Scultping details from one Mesh to another? 
Thank you and have a nice day!