I’m a huge fan of ZBrush. I had tried it years ago, but couldn’t really do much with it (confused by the interface etc). Tried it again recently, and gave the entire manual a full read through, and am hugely impressed and sold.
Some things still bother me, though, and I feel they really take away from an otherwise amazing program. So, here’s my suggestions. I totally respect other people’s preferences, and that the interface and ways have been established for a long time… so, as always, I suggest that these changes would be made OPTIONAL to the user, so that people used to or preferring the current ways can keep it so.
-Have the ZBrush window respect the Windows toolbar (not cover it up). I read that I’m not the only one asking for this.
-Have the ZBrush window minimize and restore (like other Windows apps) when the ZBrush bar in the Windows toolbar is clicked
-Allow the keyboard shortcuts to be redefined/changed by the user… PLEASE!!!
-Have the option to hold down a certain shortcut key, and have the left, middle and right mouse button (+ mouse drag) move/rotate/scale the tool. Ex. Middle mouse button held down and mouse dragged = Rotate
-An option to have menus/windows stay open until the user CLICKS outside of it (rather than just closing when the pointer goes off it)
-Option to scroll side trays with mouse wheel when pointer is over the tray
Just allowing the user to create his own keyboard shortcuts would allow me to make a workflow that I am more comfortable with, and would address a lot of the frustration I have with the interface.
Again, I would suggest that these be OPTIONAL, as not to upset those users who are either used to or prefer the current methods. I find things like the current ‘hold down ALT, drag the mouse, let go of ALT while still holding down the mouse button’ just to scale, is a bit cumbersome. A more conventional ‘hold a button, and drag the mouse’ approach would be so much more welcome.
I hope you can address some of these things. Please relocate this post if it’s not in the appropriate area. I couldn’t find an official ‘Requested Features’ thread… 
Cheers!