Ok, i’ve now noticed that the primary Startup time killer is the amount of materials in your ZStartup\Materials Folder!! 
Having so many Materials also screws up your ZBrush because the Material window is not big enough! You can't even Scroll either, your Top Row Materials are cut off above your screen!
Now, I like to have all 300+ Materials at my disposal, but This startup time is killing me, and I can't see all of them Properly anyway :confused:
<u>So, here's a way to fix this Material Browser Problem, and Make your ZBrush Start up like a Fox on steroids:</u>
- Download the "Materials Mega pack 500" Plugin. It's got useless materials but you can replace them all with your Own, Professional Looking Materials!
- Delete all the ones that come with the plug-in (in ZPlugs\MegaPack2Data), and rename your own collection to "MP1.zmt" ...to... "MP500.zmt" (You may also use less if you don't have 500) and copy those to ZPlugs\MegaPack2Data
Google for a re-naming program to do this for you (I used "[ReNamer](http://www.snapfiles.com/get/denrenamer.html)") as it's much easier :laughing:
The browser is Super cool, Fast, and you can press "5" to access it when needed.
I now have 0 materials in my Materials Folder and my ZBrush Starts up like a Dream! Plus you get a Kick-Ass Material Browser!
Hope you guys like this Tip :+1:
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After uploading around 20 mats into my startup folder I’ve noticed that the Load button didn’t function any more so I immediately installed the plugin and have been using it for a long time now… same goes for the Alphas 