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Question about mem choice in Zbrush preferences help me

Hi guys
How can I make my costume program ZBrush to take enough space of RAM memory to avoid closed while working such as working on any number of millions of Poly or i make UVs or Zremesher…etc
I found Mem. option in the Panel preferences and default value of 256 How to me that more value to work uniforms ZBrush widely and better without crashed ? and how i keep my setting whenever i open zbrush ?

i working on PC :

Windows 7 Ultimate 64-bit
CPU 2 Core duo
Ram 4 GB
VGA Ati 4350 HD
ZBrush 4R6

With your system you should leave the settings as they are. ZBrush will have already decided on the best settings.

You don’t have very much RAM on your system. The OS will take about half what you have got leaving 2GB for your apps. If you want ZBrush to run efficiently you should run it on its own, then it will have access to up to 2GB which 4R6 can access.

If you want to be able to handle larger meshes you should do two things:

  1. Increase the amount of RAM in your system. Even 2GB will make a difference.
  2. Upgrade to ZBrush 4R7. This is free for registered users. You will then be able to run the 64bit ZBrush which will make better use of the available memory (though it will only make a difference if you increase the RAM as suggested above).