Hi there, this is the first time I’ve encountered this issue with Zbrush.
You see, whenever I paint say in my example a red paint on the texture and and click Create>New from Polypaint the red disappears and always ends up with the old texture (below)
I really wanna bang my head to the wall right now since I’ve been trying to solve this problem by going through google to no avail. After hours and hours and hours of repeatedly trying to texture my model I still end up with the same thing. I tried texturing the tools such as Nickz, Dog and Demo Soldier. everytime I click New From Polypaint it still does the same problem 
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sorry if I was unclear, I wasn’t able to type out the problem out of frustration:rolleyes: I tried painting the Dog tool and Nickz in zbrush and whenever I click New from Polypaint it just gives me this blank white texture, but whenever I paint a simple sphere I have no problem clicking new from polypaint. the texture always updates. Which is really weird.

Looks like I’ll stick to Multi Map Exporter for now but I’d sure like to know what’s causing this problem.