So it seems like randomly on certain sculpts my Layer Brush will do nothing. None of the Layer brushes will do anything. I’ve played with the texture, alpha, etc, and still nothing. But if I switch to another tool it will work. So I must have some weird checkbox checked or something on the one that won’t let me use Layer? Anyone know?
Sometimes my Polish brushes stop working in this release. Just up and stop while everything else is working fine, the entire range of polish brushes just start failing, so I can relate.
The way that always works to fix that is to reboot zbrush, then they’re fine again.
But I’m going to assume that you did that already since it’s probably the first thing anyone would try.
Now, with Layer brush, it’s dependent on the Morph Target to stabilize it’s depth information. Once you’ve stored a Morph, and then sculpted with the layer brush to a certain height, no matter what you do, you will not be able to sculpt more height information and it will appear that the brush is doing nothing at all.
Until you delete your morph target or create a new one, then the Layer brush works fine again, adding more depth info. Check that you didn’t create a morph target on the mesh giving you problems, you might have, and then “used up” all of the Layer brush’s height on that mesh. Reset the morph or delete it, then try to use the Layer brush again. If that doesn’t work then I’ve got nothing, someone else will have to chime in if they know.
Yeah, I tried restarting. I tried creating and deleting morph targets. Nothing. But thanks for the attempt. 
Yep. this is yet another feature in zbrush… The layer brush also sometimes likes to crash zbrush when I have part of the model hidden… 
Can’t wait to try out the animation features in zbrush 4