I had a few problems on my Intel Mac after the latest automatic mega update of OSX.
I had to go and download the full patch which then resolved the little headaches.
http://www.apple.com/support/downloads/macosx1049comboupdateintel.html
So, if you have one or more apps which do not want to start any more, then download and run that upgrade. Completely harmless, you can run it even when the automatic update was applied. I bet it was somethign with the permissions or so, but I am to lazy to drill deeper. The Full Download solved everything.
Cheers
Mac Lemo