At some point at work I started wondering about that. This model has 8 subD levels topping at 15 mio polys…with 3 separate layer details added so far. It feels like Zbrush is having a hard time stepping up and down between the subD levels - also when parts of the model is isolated.
It’s not unusual to wait sometimes 7-10 seconds moving up and down, especially between the top levels. Probably a minor detail but it can get really annoying during a daily workflow. You just want those existing levels to shift instantly - no delay! 
Wel maybe my settings is wrong? Any know?
I work on a windows 7, dual quad core I7 processor system with 12 gigs of memory.
My Mem settings in Zbrush is:
- Compact Mem: 4096
- Doc Undo: 4
- Tool Undo: 4
- MaxPolyPerMesh: 21.2806
- HD Preview MaxPoly: 10.64
Cheers!
