Thanks for the links and advice. 
Previously I’ve only done a few head and skull sculpts from cube and sphere primitives in ZBrush (just the first few tutorials from the Scott Spencer Character book and much of the first Eat3D DVD). This is basically my first crack at doing anything with the program beyond the sculpting brushes.
Watching the tutorials, it seems that there are two main methods of approaching the ZSpheres… one where you block in the basic form and sculpt on the adaptive skin made from that foundation (what I was attempting to do above) and the other is to use the ZSpheres as an armature and then ZSketch on top of it?
Assuming that the second method will give me a more easily reposable result, I’ve remade my ztool with an almost skeletal structure and plan on ZSketching musculature over top of it.
Of course, as seen below, now that the zspheres will merely be used as an armature my adaptive skin preview is working as expected (I honestly have no idea what I did differently this time). :lol:
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