Piggy, you might want to read the above posts and your own again carefully, because what you just wrote can be pretty confusing for someone who is new to this.
If Mikaidesu is fairly new to this, which I assume by his post, then it is either way very useful for him to learn about line flow, or at least which topology works in Zbrush and which causes problems like pinching poles etc…
Now - yes if he can just start a model in Zbrush with Zspheres fore example, he is good to go and doesn’t necessareky have to worry about line flow right away, but once he is done with the sculpting and wants to get his model out of Zbrush then what? Latest at that point he can need all the info he can get about how to best achieve a good retopo model.
furthermore, it all depends on what what one actually wants to do. If you you just want to sketch along and don’t quite know yet with what kind of model you’ll end up, then its by all means good to just load Zspheres and zsketch away. If you already have a pretty precise vision or a even a concept sketch of what you want to create, then starting with a base mesh which topology already supports what you envision, then I’d rather go with that, because a good line flow certainly doesn’t hurt. especially when it comes to human faces, because all faces share a certain basic flow anyway, which is the reason why most good head meshes look very similar in terms of edge flow.
last but not least - understanding line flow, edge loops and good topology
naturally so you almost automatically build that way without having to think hard about it every time you model takes time and practice. I remember when I started that I spend more time trying to figure how to redirect edges, avoid n-gons and triangles while not shooting my polycount through the roof, than actually doing anything creative. if you do it often enough it starts to all come just naturally. it’s just like with anatomy where first starting to study all the bones, muscles and tendons and their interactions can be slightly overwhelming until some day you know that stuff by heart.
bottom line - learning and knowing the basics NEVER hurts and give you freedom in your creativity on the long run.