naw, man. What I am talking about is re-importing. What works best for me is to disable UVs withing Zbrush then export the OBJ or what have you with Grouping turned off. (if grouping is on and you have polygroups, the model will be divided on export preventing re-import from being possible). do you mapping in desired program then export to a file Zbrush can import. As long as you import/export properly and do not cut or create anything on the mesh, the vertex order should remain unchanged. The vert order is importnant because when you go to the level one subdivision on your model in zbrush, you can import into that level. All the subsequent subdivisions line up to the vertex order. Get it out of whack and the polygons will explode all over the place, but if the order is unchanged, the model should look just as you left it, but with a new UV map. Do it right and there should be no need at all to resculpt your meshes.
in summary. Point count must be identical for re-import to function, vertex order for the higher subdivisions to re-apply properly.