I think Vista SP1 (about 8 months ago) fixed most of them. SP2 (about a month ago) certainly got more. I have Vista64 running on a handful of machines here and don’t have problems with most current games and all our software (Adobe, Microsoft, Autodesk, Pixologic, Roland, Yamaha/Steinberg, Native Instruments, etc., etc.) seems to work just fine.
Vista isn’t quite as snappy in the interface with Aero turned on, but this can be turned off. Vista does a lot of background processing to keep your file system indexed. This is real handy when quickly searching for lost files, memos, emails, client assignments, etc. you can’t fine, but can chew up background cycles. It can be shut off with 3rd party tools if you don’t like it.
Program launching in Vista SP2 is almost as fast as XP.
Another rap on Vista initially was the lack of 64-bit drivers when it first came out. That has been pretty much resolved with most current hardware we use.
We expect we’ll go to Windows 7 once our software vendors are ready, but that won’t be likely until next year. In the meantime, 64-bit systems let us get a lot more done.