I made a piggy from ZSpheres, in lowres I started sculpting until I reached a density of 5 (Pig 1 and 2). Number 3 is set at density 4 and all the sculpting is gone (sure it was well sculpted at this level!).
Then I rotated the spheres of the legs (at density 5), also at this level the shape changed. I rotated the legs just a bit back, and all was ok.
After changing the pose of the arms the hands became realy bad.
WHY??
While the ZSpheres are visible, you need to press Tool>Morph Target>StoreMT before you begin posing the figure, texturing it, or sculpting the preview. This tells ZBrush to use the skin calculated from the default pose every time you preview the mesh, rather than calculating a new skin each time.
Thanks Aurick, I will try it
Works great!! 
Hello to you all,
I’m new to zbrush and I do not understand how I can pose a figure after I converted the zspheres to an adaptive skin mesh?
When the Zpheres are converted to a poly-mesh how can I put my character in a differend pose?
Sorry for this post in your topic Bas Mazur.
Peace,
Rich-Art. 
You don’t make an Adaptive Mesh. When you want to be able to pose a ZSphere model all the sculpting, posing and texturing is done to the Preview (hotkey ‘A’). Just follow aurick’s instructions above and you should be fine.
Thanks for the reply.
I did not know that it is not nessecary to make a adaptive skin.
Great.
Peace,
Rich-Art. 
You are welcome. 
One thing: make sure that you have finished the ZSphere bit of your model before storing the morph target and sculpting/posing the adaptive skin: adding or deleting zspheres later will destroy the mesh.
Thanks again. I’ll try to rember this. lol
I’m using Cinema4D for a couple of years and it is a bit hard to switch to the Zbrush interface and the way I have to use Zbrush.
I think to much in classical 3D modeling style.
But with a big can of coffee and some time, I’ll be able to make some nice characters with zbrush.
Peace,
Rich-Art.
hmm that is strange about every tutorials movie i have seen made it into an adaptive skin?
Are there any advantages to turn it into an adaptive skin, as it seems better to me when you can pose your character.
Well, you can only pose it this way in ZBrush. The Adaptive Skin enables you to export to other programs which is an important step for many people. It depends what you are doing.
From the hints that have been flying around about ZB 2.5 I would expect greater control in mesh posing in the update. And then all it will need is a talented zscripter to provide a plugin for exporting bones.