I have two or three setups, depending on where I am (office, home study, or easy chair)
My “office setup” is big Cintiq and auxiliary 23" LCD display. It’s an ordinary desk, about 54" long and 30" deep top. The mouse and pad is on the right an the keyboard is off to the left and I operate it mostly with my left hand. If I need to type (like now, I pull the keyboard to center. I have handwriting recognition and virtual keyboards on my cintiqs in case I don’t feel like typing on a keyboard.
My easy chair setup is a little more unique. I have a small table that was custom built (actually a modified tray table from Frys) on the right side where I set my laptop and it holds power, network connection, and connector box for my Cintiq 12Wx underneath. My wireleass keyboard is held to the left arm of the easy chair by velcro which is held in place by nylon straps. The keyboard normally rests on the left arm, the 12wx in my lap, and the computer on the table. Most of the time I can hit keys with my left hand as needed without reposition the keyboard, but when I need to type a memo, I just put the keyboard in my lap with small cintiq propped up in my knees. (This is not as uncomfortable as it sounds, the foot rest is supporting my feet.
I actually find that I like being able to work with the smaller cintiq’s in my lap rather than the bigger setup when I’m just free sculpting. The bigger setup is much better for the construction of scenes, surfacing, and working on images. It feels less like “work” when I’m just doodling away with display in my lap. 
-K