I was just watching an old pixolator video that was a fish being sculpted from Z Spheres. In it, the artist was going back and forth between the states of the Z Spheres and Preview mode and doing adjustments on the mesh with different brushes. Any time that I have ever tried to do this, my mesh explodes. Most times that it has happened it was because I made a minor adjustment to a Z Sphere and then switched back to preview.
I guess my question is if you are going to model a Z sphere mesh and still want to see it in preview mode, do you have to make sure that your mesh is in the position that you want it in before you start?