Continuing the discussion from Using Zbrush on Linux:
Hi all ZB on Linux folks,
I’ve installed ZBrush 2021.5 with using Lutris / wine 6.0 rc-1. It’s running good on Ubuntu Linux 20.10. It still have the Lightbox issue, but overall most functions are working fine.
Just wanted to report & share the info. Any comments and reports are welcome.
Here are the Lightbox condition as a default installation.

hope this helps and more info / report will come from anyone.