This device might be the answer for impenetrable interface difficulties. Now you should be able to use extremely different CAD interfaces with somewhat equivalent shortcuts AND map them yourself with just one (self-labeled) button. Just one button access to any CAD shortcut key combo. I think this is at least 50% of the interface problem.
http://www.piengineering.com/xkeys/xkpro.php
Has any Zbrush user gained experience with this simplifying device inside ZBrush?
For Mac users, OSX 10.4.3 should work according to them (but earlier 10.4.2 had problems with it).