First thing is I’m unaware (doesn’t mean it doesn’t exist) of any 3D printer large enough to print a 2x2x2 meter ball in one piece. Are you planning on splitting this into smaller pieces? As far as resolution, yes you should try to emulate what the actual scale would be on your screen (you’ll obviously only be able to view a small section) to verify appropriate resolution for you model. If you were sculpting a car exterior & wanted to build it via 3D printers you would also have to make sure the resolution matches the scale just like with anything else.
If you’re looking to have it CNC’d then that could change alot of things but not so much if you’re making the model in ZB. Even though many CNC CAM packages can now read STL files they typically have used more traditional CAD formats (STEP, XT, IGES, etc) which your Nurbs program (ie Rhino) would be perfect for. You will not be able to develop the high level of organic sculptural detail like you can in ZB though. Also, with CNC you are limited in detail by cutter size. While it is possible to get cutters just a few thousandths of an inch in diameter or even with cone tip points it becomes prohibitively time consuming to make all the passes over a large surface with that fine of a cutter.
There are many process & technologies on the market that all build differently as far as resolution, material, speed, etc. Finding the best one for you is typically a balance between the scale of your model (larger requires less printer resolution), budget, & material requirements. Read through my tutorial on 3D printing tutorial to learn more about the different processes & their individual pros & cons.
Depending on what your model is you may want to consider having it machined in aluminum or having it printed in a burnable material that can be used as a pattern for casting (see my thread on my cast bronze tangles ). There are also some process that print in metal. Do a search for 3D metal printing to get you started learning about them.