Since I am also using Photoshop and Sketchbook, I have to say that this cannot be a (solely) Wacom driver related issue since Autodesk released an update to Sketchbook Pro which now works perfectly under Lion, no lagging at all.
And Photoshop never had the problem with any of my computers to begin with.
I do think this is a hardware related issue, since ZBrush works fine on the Mac Pro but all other machines show problems. However, given the fact that Sketchbook worked fine on the Mac Pro as well but not on the other computers but now, after the update, it does, I would strongly suggest that Pixologic gets their act together and stops putting the blame on Wacom, simply stating that they do not have this problem because they seem to be unable to reproduce what many users experience. It is their job to find out what is causing the problem and to find a solution.
Maybe there is a correlation between ZBrush and Wacom, but the problem cannot be solely on Wacom’s side, otherwise Autodesk would probably not have been able to fix the problems people had with Sketchbook Pro.