I just got a Nostromo yesterday. I’m really liking it, but the scroll wheel stops working after a short while. And doesn’t seem to want to start working again until the machine is rebooted. So far I have only used it with ZB. I have tried mapping the wheel to “]” and “[” as well as “D” and “Shift-D”.
If you have a cintiq (or like to have your tablet in front of you) and can’t find a good spot for your keyboard, you might want to think about getting one of these 
Any help on this or other tips for the Nostromo would be great =)