Hello Aris,
Generally speaking, once a mesh is rotated off axis, the time for symmetrical operation has passed. In every scenario, it would be better to simply complete your symmetrical operations before doing this.
However, you have some options.
Turning on Local SYmmetry (L.SYM) for a mesh will cause the symmetry operations to use the subtool’s own local center for operations. This can be used for meshes that are symmetrical in themselves, and have been moved away from the tool center. It will not work if the meshes have been rotated.
In this particular scenario, assuming the topology is actually symmetrical from side to side, it would probably work with Poseable Symmetry. Poseable Symmetry has specific requirements and limitations for the situations it will work with. Please read the documentation carefully.
You can also use the NanoMesh Edit Mesh functionality to place instances of the mesh that have been rotated or posed in space, while working on the original mesh in Symmetrical Space.
All of these approaches have limitations, but may give you more flexibility in specific situations. The most reliable approach, again, is to just complete that portion of your modeling before rotating or posing your mesh.
Good luck!