Hi @tapten64,
There are two likely possibilities.
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There is an issue with the mesh geometry being used that is preventing the process from working on that file.
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There is a general issue with either the installation or the installation environment that is preventing it from working with any file.
In both cases you will need to contact Support for technical assistance with ZBrush. We aren’t able to assist you with those types of problems over the public forums.
Since I can’t assist you further here I’m going to close this thread ONLY so you don’t feel you’re being ignored when no further assistance is provided. I’d like to encourage you to contact us where we can help you.
Thank you!