hey Alex awesome heads BTW.
I found really nice modelling with Zspheres .
z brush really make you feel like modelling in clay, so that natural shapes are easier to achieve because you’re focused on the shape rather than on polys, isolines or things like that.
I think that for now, even if starting from zspheres is so cool and natural, the best workflow for animation ZBrush /Maya is starting with a mesh with a good polyflow made in Maya or another package,(or also started on zbrush, then imported and tweaked and reimportedafterwards for further cool detailing) import it in z brush and go beyond and detail and model your final extra detailed character in it.
the opposite process of making a model entirely on ZBrush and rebuild it with silo is interesting too, but i find this probably more time consuming than the standard process.
BTW modelling in Z brush is such a pleasure that IMO if it had a rebuilding polyflow tool or something the circle would be closed ending up with the ultimate tool for organic modelling!!! 